No Superoxide Dismutase Activity of Cellular Prion Protein in vivo
نویسندگان
چکیده
منابع مشابه
Prion protein expression and superoxide dismutase activity.
The function of the prion protein (PrPc) remains uncertain. It has been suggested that prion protein expression may aid cellular resistance to oxidative stress by influencing the activity of Cu/Zn superoxide dismutase (Cu,Zn SOD). The activity of Cu,Zn SOD was investigated in mice with different levels of PrPc expression. Increasing levels of PrPc expression were linked to increased levels of C...
متن کاملNormal prion protein has an activity like that of superoxide dismutase.
We show here that mouse prion protein (PrP(C)) either as recombinant protein or immunoprecipitated from brain tissue has superoxide dismutase (SOD) activity. SOD activity was also associated with recombinant chicken PrP(C) confirming the evolutionary conserved phenotype suggested by sequence similarity. Acquisition of copper by PrP(C) during protein folding endowed SOD activity on the protein b...
متن کاملGPI-anchorless human prion protein is secreted and glycosylated but lacks superoxide dismutase activity.
Prion protein (PrP) is a glycosylphosphatidylinositol (GPI)-anchored membrane protein that is thought to play a role in anti-oxidative stress. It remains controversial whether PrP elicits superoxide dismutase (SOD) activity itself or indirectly by activating cellular SOD. Our previous studies showed that soluble PrP produced by a baculovirus expression system did not exhibit any SOD activity in...
متن کاملSuperoxide dismutase activity in leukocytes.
Superoxide dismutase activity has been identified in both human neutrophils and rabbit alveolar macrophages by two distinct assay procedures. The enzyme is insensitive to both cyanide and azide and is present in the cytosol of the cell. The identification of this enzyme in phagocytic cells is compatible with the theory that superoxide anion might be involved in the bactericidal activity of the ...
متن کاملthe plasma antioxidant activity of superoxide dismutase enzyme in osteoporosis
osteoporosis is a metabolic disease characterized by reduction in bone density and susceptibility to deformity and fracture. some studies show that osteoblasts can create inter-cellular free radicals that lead to cellular death. superoxide dismutase (sod) plays an essential role in cell defense against reactive oxygen metabolites. the purpose of this study was to measure the plasma sod activiti...
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ژورنال
عنوان ژورنال: Biological Chemistry
سال: 2003
ISSN: 1431-6730
DOI: 10.1515/bc.2003.142